JAN STUNDL, Ph.D.
 
 
 
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About

My scientific journey began in Dr. Robert Cerny's Lab at the Charles University in Prague where I was first introduced to the captivating realms of embryology and evo-devo. While pursuing my Ph.D., I participated in the 2017 Embryology Course at the Marine Biological Laboratory in Woods Hole, Massachusetts. This experience deepened my passion for studying the intriguing and diverse organisms that play crucial roles in expanding our understanding of evolution and development. My dissertation thesis focused on analyzing cranial neural crest migration and differentiation in several fishes with an emphasis on all basal lineages, including bichirs and sturgeons. For post-doctoral studies, my goal was to gain a more in-depth understanding of the neural crest at a molecular level. To this end, I joined the laboratory of Professor Marianne Bronner at the California Institute of Technology. To study the possible role of the neural crest in both development and regeneration in non-models like lamprey and sturgeon, I was awarded a Marie Sklodowska-Curie Postdoctoral Fellowship funded by the European Union (co-hosted by Caltech in the US and the University of South Bohemia in Czech Republic).

 

Positions and Professional Stays

  • Marie Sklodowska-Curie Postdoctoral Fellow, Bronner Lab & Psenicka Lab - Caltech, USA and University of South Bohemia, Czech Republic (2021-2023)

  • Postdoctoral Scholar, Bronner Lab – Caltech, USA (2019 - )

  • Guest PhD student, Haitina Lab – Uppsala University, Sweden (2017)

  • Guest PhD student, Olsson Lab – Friedrich-Schiller University, Germany (2015-2016)

  • PhD in Zoology, Cerny Lab – Charles University, Czech Republic (2013-2019)

  • Researcher, Natural History Museum – National Museum, Czech Republic (2012-2019)

 
 
 
 
 
 
 
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Research

Development and evolution of the neural crest odontoskeletogenic ability

The neural crest is an important stem cell population in the evolution and development of vertebrates, playing a key role in evolving predatory skills and expanding the skull and brain. In vertebrate embryos, the neural crest divides into several subpopulations based on origins, such as the cranial, vagal, and trunk neural crest. Although all these populations share a common set of genes, they are also unique depending on their specific region of origin along the body axis. I use comparative molecular analyses and cell lineage analyses to investigate the developmental potential of neural crest cells across early branching lineages of vertebrates, such as lampreys and sturgeons. My particular focus is on their odontoskeletogenic ability to produce hard tissues such as bone and dentin. The results from these analyses will provide a comprehensive understanding of the molecular mechanisms and alterations within specific developmental programs along the body axis, emphasizing what confers the ability to make bone or dentin.


Selected Publications

 

neural crest and its role in regeneration

The capacity for scarless regeneration seems to have gradually diminished throughout vertebrate evolution as tissues and organs increased their complexity. Thus, 'basal' vertebrates serve as valuable model systems for gaining deeper insights into tissue repair abilities, as they may unveil ancestral regeneration mechanisms. To study this, I employ a comparative approach, focusing on lampreys and sturgeons, both renowned for their exceptional regenerative potential and important phylogenetic position. Regeneration is a multifaceted process involving various cell populations, with glial cells emerging as particularly significant players. Notably, neural crest cells form all of the glia in the vertebrate peripheral nervous system, raising the possibility that they may represent a stem cell-like population that can repair vertebrate tissues. Thus, my research aims to investigate the role of neural crest stem cells in promoting tissue repair (e.g. heart tissues - supported by MSCA No. 897949) in vertebrates.

 

 

RECONSTRUCTION OF THE DEVELOPMENTAL CHANGES UNDERLYING THE EARLIEST EVENTS IN VERTEBRATE EVOLUTION

To comprehend the developmental programs driving evolution of the early vertebrate body plan, I utilize a comparative approach, studying a diverse range of phylogenetically important non-model organisms such as lamprey and sturgeon alongside established models like zebrafish and salamanders. I primarily aim to decipher the developmental roles of neural crest and mesodermal cells in the formation of vertebrate skeleton and larval organs.

Selected Publications

 
 

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PUBLICaTIONS

This research received public funding. If you encounter any difficulties accessing the articles listed below, please feel free to contact me.

View all publications »

GENERATION OF A ZEBRAFISH NEUROFIBROMATOSIS MODEL VIA INDUCIBLE KNOCKOUT OF NF2. Desingu Rajan, A. R., Huang, Y., Stundl, J.,, Chu, K., Irodi, A., Yang, Z., Applegate, B. E., Bronner, M. E. (2024). Disease Models & Mechanisms, dmm.050862.

TLX3 MEDIATES NEURONAL DIFFERENTIATION AND PROPER CONDENSATION OF THE DEVELOPING TRIGEMINAL GANGLION. Urrutia, H. A., Stundl, J.,, Bronner, M. E. (2024). Developmental Biology, 515: 79–91.

NEURAL CREST ORIGIN OF SYMPATHETIC NEURONS AT THE DAWN OF VERTEBRATES. Edens, B. M., Stundl, J., Urrutia, H. A., Bronner, M. E. (2024). Nature, 626: 121–124.

A LAMPREY NEURAL CELL TYPE ATLAS ILLUMINATES THE ORIGINS OF THE VERTEBRATE BRAIN. Lamanna, F., Hervas-Sotomayor, F., Oel, A. P., Jandzik, D., Sobrido-Cameán, D., Santos-Durán, G. N., Martik, M. L., Stundl, J., Green, S. A., Brüning, T., … & Kaessmann, H. (2023). Nature Ecology & Evolution, 7: 1714–1728.

PRE-MANDIBULAR PHARYNGEAL POUCHES IN EARLY NON-TELEOST FISH EMBRYOS. Horackova, A., Pospisilova, A., Stundl, J., Minarik, M., Jandzik, D., Cerny, R. (2023). Proceedings of the Royal Society B: Biological Sciences, 290: 20231158.

ANCIENT VERTEBRATE DERMAL ARMOR EVOLVED FROM TRUNK NEURAL CREST. Stundl, J.*, Martik, M. L., Chen, D., Desingu Rajan, A. R., Franěk, R., Pospisilova, A., … & Bronner, M. E.* (2023). The Proceedings of the National Academy of Sciences (PNAS), 120: e2221120120. * co-corresponding authors

- > Commentary for PNAS written by Andrew Gillis

A MEDIAN FIN DERIVED FROM THE LATERAL PLATE MESODERM AND THE ORIGIN OF PAIRED FINS. Tzung, K. W., Lalonde, R. L., Prummel, K. D., Mahabaleshwar, H., Moran, H. R., Stundl, J., ... & Mosimann, C., Carney, T. J. (2023). Nature, 618: 543–549.

EVOLUTION OF THE NITRIC OXIDE SYNTHASE FAMILY IN VERTEBRATES AND NOVEL INSIGHTS IN GILL DEVELOPMENT. Annona, G., Sato, I., Pascual-Anaya, J., Osca, D., Braasch, I., Voss, R., Stundl, J., ... & D'Aniello, S. (2022). Proceedings of the Royal Society B: Biological Sciences, 289: 20220667.

THE REMARKABLE DYNAMICS IN THE ESTABLISHMENT, REARRANGEMENT, AND LOSS OF DENTITION DURING THE ONTOGENY OF THE STERLET STURGEON. Pospisilova, A., Stundl, J., Brejcha, J., Metscher, B. D., Psenicka, M., Cerny, R., & Soukup, V. (2022). Developmental Dynamics, 251: 826–845.

EFFICIENT CRISPR MUTAGENESIS IN STURGEON DEMONSTRATES ITS UTILITY IN LARGE, SLOW-MATURING VERTEBRATES. Stundl, J., Soukup, V., Franěk, R., Pospisilova, A., Psutkova, V., Pšenička, M., ... & Jandzik, D. (2022). Frontiers in Cell and Developmental Biology, 10: 750833.

EVOLUTION OF NEW CELL TYPES AT THE LATERAL NEURAL BORDER. Stundl, J., Bertucci, P. Y., Lauri, A., Arendt, D., & Bronner, M. E. (2021). Current Topics in Developmental Biology, 141: 173–205.

MIGRATORY PATTERNS AND EVOLUTIONARY PLASTICITY OF CRANIAL NEURAL CREST CELLS IN RAY-FINNED FISHES. Stundl, J.*, Pospisilova, A., Matějková, T., Psenicka, M., Bronner, M. E., & Cerny, R.* (2020). Developmental Biology, 467: 14–29. * co-corresponding authors

EMBRYONIC AND LARVAL DEVELOPMENT OF THE NORTHERN PIKE: AN EMERGING FISH MODEL SYSTEM FOR EVO‐DEVO RESEARCH. Pospisilova, A., Brejcha, J., Miller, V., Holcman, R., Šanda, R., & Stundl, J.* (2019). Journal of Morphology, 280: 1118–1140. * corresponding author

BICHIR EXTERNAL GILLS ARISE VIA HETEROCHRONIC SHIFT THAT ACCELERATES HYOID ARCH DEVELOPMENT. Stundl, J., Pospisilova, A., Jandzik, D., Fabian, P., Dobiasova, B., Minarik, M., … & Cerny, R. (2019). eLife, 8: e43531.

PRE-ORAL GUT CONTRIBUTES TO FACIAL STRUCTURES IN NON-TELEOST FISHES. Minarik, M., Stundl, J., Fabian, P., Jandzik, D., Metscher, B. D., Psenicka, M., ... & Cerny, R. (2017). Nature, 547: 209–212.

 

 

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outreach

My Research Photographs Featured at European Researchers' Night 2023: 'Mystery' (Tajemstvi Ryb)

 
 
 
 
 
 
 
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Contact ME

 
 
 

Jan Stundl, Ph.D.

Postdoctoral Scholar Research Associate in Biology and Biological Engineering

California Institute of Technology

Pasadena, California 91125

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